The appointment follows a review which also included the incumbent Ogilvy & Mather, Grey Worldwide and Scholz & Friends (Campaign, 17 January).
O&M has been retained to handle local implementation .
The focus of the new TV and print campaign will be Europe, but the work will also run in Asia and the US.
The move comes as DHL's owner, Deutsche Post, seeks a major overhaul of the brand's positioning and marketing.
This follows ownership changes late last year, whereby Deutsche Post increased its holding in the brand to 100 per cent and decided to bring together its express and parcel and logistics businesses under the global DHL brand.
As reported by Campaign, media planning and buying will be divided between Carat in Europe and Mediaedge:cia for the rest of the world. In terms of spend the split is roughly 50:50.
O&M originally picked up the global business last July following a review out of the DDB network. However, the ownership changes prompted the latest rethink.
DHL is the world's biggest ground and air express service. Deutsche Post is one of the largest high-performing logistics companies in the world.
In 2001, it generated revenues of 33.4 billion euros.