The new agency, which will take the name KK Outlet, is due to launch this summer and will open its doors in East London, although an exact location has yet to be decided.
Yen Yen Ho, the former head of account management at Bartle Bogle Hegarty Singapore, will head the offshoot alongside Erik Kessels, the co-founder and creative director of Kesselskramer.
According to Kessels, the London base will not be a carbon copy of the Amsterdam operation.Instead, it will take the form of a shop, gallery and workspace in one.
Kramer, who plans to divide his time between the London and Amsterdam offices, set up the original agency with his co-founder Johan Kramer in 1996. Kramer, however, left in 2004 to concentrate on directing full time.
Yen Yen has previously worked for the agency in Amsterdam, before leaving to help set up BBH's Shanghai office.
Since it launched 11 years ago, Kesselskramer has made ads for brands such as JB whisky, Levi's, Nike and Oxfam.
Kessels said: "Our ambitions are not to build a huge agency. We want to concentrate more on quality than quantity. The field of communications is so much broader than advertising on its own, and over the years we've spread into different fields and we want to bring that expertise to London."