The campaign, developed by Euro RSCG London, begins on 24 May and will feature in magazines including Condé Nast’s Glamour and IPC Media’s Now.
Promotiions will run on the sides of buses in London, Birmingham, Bristol, Edinburgh, Glasgow, Leeds, Leicester, Liverpool, Manchester, Newcastle and Sheffield. In addition, there will be 48-sheet billboards in 12 cities and scrolling digital boards at the Westfield shopping centre in London.
Lisa Bond, marketing and PR director at La Senza, said: "This advertising campaign is going to be the most talked-about on the high street and reflects the playful and stylish elements of the La Senza brand."
The campaign is the first work since Euro RSCG London picked up the La Senza account earlier this month.
La Senza brand ambassadors have included model Sophie Anderton and former Hollyoaks actress Gemma Atkinson. Last year, the retailer launched a Christmas campaign featuring TV presenter Tess Daly.
The retailer recently rolled out an "Armed Forces" campaign featuring current Miss England and serving soldier, Kat Hodge.