Latimes.com, which is one of the fastest growing US newspaper websites, has already seen its blog network expanded and added more interactive content.
Now the navigation has been streamlined at the top of every page, making it easier to access big stories from wherever users are on the website.
Advertising will no longer appear in the middle of stories, so they are easier to scroll through, and there will be more scope for sharing stories on social networking sites.
The video player has been updated so that it loads faster and it also has more sharing options.
The site's font has also been updated from Arial, which is sans serif, to Georgia, which has serifs.
Meredith Artley, managing editor of online at the LA Times, said in a blog post announcing the changes: "Our work is not done. We approached this redesign as another step in the evolution of the Los Angeles Times, as a building block for more things to come."
Comments from readers on the blog post are largely positive, although a few declared the new design to "stink" and others said they preferred the older look.
The LA Times is owned by Tribune, which filed for bankruptcy protection in December.