There will be an interactive "brick-filled experience" across the whole of the top floor of the gallery.
Visitors will be able to take in four zones with themes including Christmas, creative, Minecreaft and galactic. Each area will have a "brick-based interactive activity".
In the Christmas zone people will be able to help build a three-metre Lego mosaic and guests can buy festive gifts. The creative area will feature a 24-metre graffiti wall to encourage people to "make their mark".
The Galactic Adventure zone will be a precursor for Star Wars: The Last Jedi, the latest Star Wars movie which is released in December. Visitors will be able to take a look at previous Lego sets and a six-feet long "super star destroyer fleet" that has never been displayed in public.
The installation will be created by Bricklive an will run from 25 November until 7 January.