The jeans manufacturer previously worked with Wieden & Kennedy, but has chosen to work with a combined team from the two agencies. Its most famous advertising was created by Bartle Bogle Hegarty, of which it was a founding client.
Levi's claims the new arrangement will allow it to tap into creativity at a local and global level.
House Worldwide was founded in March 2013 by former Publicis Worldwide chief operating officer Richard Pinder.
Pinder said: "Levi’s is the brand whose advertising in the '80s convinced me to get into the industry. To win this account is a dream come true."
OMD remains Levi's media agency.