The review is being handled by the AAR, which is understood to have contacted agencies about the brief.
Marie Curie spends £2 million on above-the-line media, according to The Nielsen Company, with the rest of the budget allocated to direct response.
The creative account, which is held by DLKW Lowe, is not thought to be affected by the media review.
At the beginning of the year, the charity launched the Great Daffodil Campaign, backed by celebrities including Stephen Fry, Tony Blackburn and Jon Culshaw.
The campaign spanned TV, radio, print and online. It was created to encourage people to contribute to the appeal by volunteering an hour of their time to go out on to the street and collect donations and signatures from the public.
James Jennings, the former joint managing director at Maxus, who left the agency last month to take a sabbatical, is credited with having run the Marie Curie account. Tim Irwin, who was promoted from his role of joint managing director to assume full managerial responsibility, has now taken over his duties.
Marie Curie Cancer Care was not available to comment on the review.