As well as working with Miramax on its ads and marketing support for films, Mother hopes to gain a foothold in Hollywood by giving Miramax first refusal on its ideas for films or TV shows.
Mother will promote Miramax's upcoming films, including Kill Bill: Volume Two and the Ben Affleck film Jersey Girl. The agreement follows the launch of Mother's New York office last year.
Harvey Weinstein, the co-chairman of Miramax, said: "This unprecedented deal gives us access to marketing strategies as well as ideas for new concepts from some of the most creative people I have ever met."
Mother already has a deal with the BBC to create a one-off programme starring ITV Digital's Monkey character, with the possibility it may be made into a series.
Mother's New York office, which is headed by Andrew Deitchman, has already won assignments from the NBA and Chipotle, the fast-food burrito chain.