An agency spokesman declined to disclose financial details but said Mother would have a significant minority holding in dRi’s business.
DRi is an independent developer that creates games and experiences on virtual reality platforms. It was founded by Dave Ranyard, the former head of Sony London Studio.
Based in London, the start-up is working on projects including "Hold the world", a Factory 42 production for Sky featuring Sir David Attenborough as a VR hologram.
This is the first time that Mother has made an investment in the AR and VR space. The agency has previously backed companies in creative communications, such as Naked, Poke, Broody, Saturday Group and The Romans.
Michael Wall, the global chief executive of Mother, said: "Mother's investments in start-ups have always been about finding great people and doing something fresh, creative and ambitious together. With Dave and his team, the creative and technological possibilities that VR and AR offer, we’ve got a whole new canvas to work with."
DRi has also secured investment from Phil Harrison, a co-founder of Playstation, former president of Sony Computer Entertainment Worldwide Studios and former corporate vice-president of Microsoft.
Ranyard added: "We are really excited by the space where AR, VR and AI meet and can see amazing opportunities for new levels of immersion and human interaction. Having backing from two successful and insightful investors enables us to accelerate our ambitions and is a huge validation of the talented team we have put together."