The skincare brand, which has ambitions to become the world's number one natural personal care brand within five years, has appointed the network ahead of an advertising push behind its products across several markets.
MPG International, which was appointed after a pitch, will handle the account from its London office with local MPG offices handling implementation and local buying across 15 markets.
The brand, which has not previously had a media agency in the UK, is expected to spend around £2 million in Britain.
David Goodall, the managing partner at MPG International, said: "Burt's Bees is an ethically responsible company and a well-respected brand across the world.
"We are looking forward to working together with it to grow its business in the UK and in many territories across the globe."