To enter the competition, fans need to create live-action videos of their own original couch gags, that are no more than 45 seconds in length, and upload them to 'The Simpsons' MySpace page.
Entrants, who must be 18 years and over, are allowed to use the audio files of 'The Simpsons' theme song, which can be found on the contest page.
The live-action videos must be submitted by May 18 and a winner will be selected by a judging panel, including 'The Simpsons' producers, on June 22.
The winner and a guest will receive a trip to Los Angeles to attend 'The Simpsons' 21st season premiere party, a home entertainment system and a custom drawing of 'The Simpsons'.
Additionally, a fan favourite winner will be chosen by users. That winner will be awarded a 'The Simpsons' prize pack.
'The Simpsons', which is the longest-running US sitcom, animated series and primetime series, moved into high definition in February. The first HD episode, called 'Take my wife, please', aired in the UK on Sky1 and Sky1 HD on February 22.