Other leading adland figures, including John Hegarty, Steve Henry and John Webster, also appear in the 80-second spot, acting the roles of people who are helped by the industry charity.
The film, shot by Chris Palmer at Gorgeous, made its debut at Wednesday's Nabs Big Bash. It coincides with news that Kate Harris is to step down as the Nabs chief executive after five years.
Harris, who will leave in May, is moving to the North of England "to explore the many opportunities presenting themselves".
Harris helped to reinvigorate the Nabs fund-raising programme. She oversaw the launch of May Day Pay Day and the replacement of the Nabs Boxing Night with the Big Bash as the charity's major annual fund-raising event.
Nabs now turns over £2.5 million and helps more than 3,000 people a year.
Grant Duncan, the Nabs chairman, said: "Thanks to Kate, Nabs is very much on the industry agenda, despite many other calls on people's attention and time."
The film, which will appear on the Nabs website, is intended to underline the message that misfortune can strike anyone at any time.
The spot was created by Will Farquhar and Ian Ducker, the former Leagas Delaney creative chiefs now running their own agency, Vinnie.
Tim North, Vinnie's managing director, said: "For young people, in particular, Nabs has no relevance. They would rather give to the tsunami appeal."