Smith will oversee the digital agency’s eight-strong creative department, working on clients including Marks & Spencer, Revlon and the BBC.
She will work closely with Dale Gall, Profero’s chief executive, and Buster Dover, the managing director.
A creative director at Havas Worldwide London since 2010, Smith created work for clients including Citroën, Kraft and Chivas Regal.
She was previously at Rainey Kelly Campbell Roalfe/Y&R, St Luke’s, AKQA and Work Club.
Clapp is leaving Profero by mutual consent.