Havas and Publicis, which are both already on Reckitt Benckiser's roster of agencies, won the business after a pitch against networks including other global incumbents Omnicom and WPP.
Agencies eliminated from the process which had previously been on the Reckitt roster include OMD, which handled the £90 million UK business.
Publicis agency ZenithOptimedia has has won the UK and US accounts, in addition to markets including Germany and the rest of Northern Europe, plus Asia while MPG will handle the business outside these markets.
Rakesh Kapoor executive vice president category development said: "We have chosen two global media partners that will bring us new consumer insights, better capabilities in technology and systems and superior skills in ensuring that we build better consumer engagement strategies and executions."
Last year, Reckitt Benckiser increased its media spend by 26 per cent to £800 million and grew its revenues by 25 per cent to £6.6 billion.
In April it reported a 35 per cent rise in profits for the first quarter of the year, defying market expectations.