Pink Scrabble will be rolled out in retailers from mid-September with Mattel making a donation to the charity for each game sold.
It is the first time since the game's launch in 1948 that its red-and-green branding has been altered. The logo, box, tiles and tile racks will all be coloured pink.
The launch will be supported by media and in-store activity to ensure the product has a premium presence. The promotional work is being handled in-house.
Mattel plans to run a celebrity campaign, though it is yet to reveal who will be involved. However, it did say that Kylie Minogue, who was diagnosed with breast cancer last year, is a Scrabble fan.