Documentaries hosted by Rod Liddle, Piers Morgan and Francis Fulford, the star of Channel 4's The F**king Fulfords, will run alongside US imports and a conservation series, Final Chance to Save, hosted by Joanna Lumley and Griff Rhys Jones.
The US sitcom Weeds, about a drug-dealing homemaker, is a key show in the schedule. It shocked middle America when it was shown in the US. Among the returning series are Nip/Tuck, Hex and Dream Team and new one-offs of The Match and All Star Cup.
Other new series include Excellent Adventure, featuring celebrities such as Minnie Driver and Harry Enfield surviving in tough environments. How Not to Die, hosted by the former SAS soldier Chris Ryan, takes viewers through hypothetical life-threatening scenarios.
James Baker, the controller of Sky One, said: "Our autumn schedule promises our strong-est line-up of programming to date. We're confident Sky One continues to bring the best from the US, with Weeds set to mirror its US reception from audiences and critics."