The agency won the business after a pitch against cdp-travissully and Burkitt DDB, and as the brand's parent company, Drambuie Liqueur, gears up for a national roll-out of the product.
Soul is currently working on the creative and media planning for the launch, with an undisclosed spend, although the media buying agency has yet to be appointed.
Drambuie Cream was initially launched in the UK in 2000, and has seen a hefty increase in sales over the past 12 months, according to the company.
The drink is aimed at a younger market than its sister brand, Drambuie Liqueur, and is made with 15-to 17-year-old malt whiskies, cream and heather honey.
Soul's managing director, Duncan Bird, said: "We are delighted to be working on Drambuie Cream at such an exciting time for the brand and the company."
Burkitt DDB is retained on the main Drambuie account, and is currently working on a new TV campaign for Drambuie Liqueur.
UDV previously handled the distribution of Drambuie's brands in the UK, but was dropped after 11 years in favour of Bacardi-Martini in May.