The agency also scooped two golds, three silvers and two bronzes at the awards, which are run in conjunction with Campaign.
Other winners included Rees Bradley Hepburn, which won the outdoor poster campaign gold for its "beer lolly" for Church End Brewery.
The outdoor poster gold was picked up by the then McCann Erickson Manchester for the "to be sure, to be sure" St Patrick's Day poster for Durex. The agency also won the consumer magazine gold with its "shag" campaign for the condom brand.
The TV campaign, TV commercial and cinema golds went to Big Communications for its work for WKD.
The prize for best website went to Uber Agency for its own site, while Tequila won a gold for its "things could get ugly" campaign promoting Miss Manchester 2005.
Paula Kelsey, the director of the Fresh Awards, said: "It is fantastic to see the quality of work involved in the Grand Prix event. It really is the best of the best."
All the winning entries from last year's Fresh Creative Awards regional competitions were entered and re-judged for the national awards.