The two-day event will be held at the Copper Box Arena in the Queen Elizabeth Olympic Park, kicking off with the TechCrunch Disrupt Hackathon followed by two days of on-stage interviews and panel sessions with some of the biggest names in technology.
Previous speakers at the event include Soundcloud founder and chief exectuive, Alex Ljung; chief executive of Twitter, Dick Costolo, and founder and chief executive of Facebook, Mark Zuckerberg.
This year's event will introduce Startup Battlefield, a feature in which competitors pitch to a team of esteemed judges for the chance to win £30,000 and the coveted Disrupt Cup.
Previous Battlefield competitions have launched companies such as Dropbox, Mint.com, Yammer and Fitbit. Another new feature for 2015 will be Startup Alley, an area showcasing around 150 start-up companies.
Mike Butcher, editor at large of TechCrunch, said: "Last year European startups raised more money than they did during the dot com boom. Much of that money and startup activity is coming out of London, as European entrepreneurs are often using it as a bridge to the Valley.
"At the same time, it remains the first beachhead for many US startups looking to scale in Europe. So there are hard and fast reasons why it made sense for TechCrunch to return to London with Disrupt."
Gordon Innes, chief executive of London & Partners, added: "TechCrunch Disrupt is one of the pre-eminent events on the global tech calendar, and I am delighted that its organisers are bringing it back to London.
"Our city is in the midst of a tech boom, producing companies and ideas that are changing the world and creating jobs and economic growth for the UK, and hosting this major event here acknowledges London’s success and shows that global attention is focused on what is being produced here."
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