The agency picked up the business in a competitive pitch against a number of undisclosed agencies.
The Manchester-based shop Connectpoint held the account for the past five years.
Tequila\Manchester will create strategy and creative executions for the channel as it looks to boost subscriber acquisition and retention.
Fergus McCallum, the chief executive of Tequila\Manchester, said: "MUTV has great potential. We're looking forward to taking the brand forward with campaigns that really appeal to the fans."
Sameer Pabari, the managing director of MUTV, added: "Tequila\Manchester's creativity did it for us. We felt that its breadth of thinking and understanding of audience were key attributes to offer MUTV."