The mobile operator has teamed up with the League Two side, giving supporters the chance to contribute to the pre-match team talk via Twitter.
It claims the match involves the longest journey for away fans in English football – a near-800-mile round trip.
Plymouth supporters' loyalty will be rewarded with a chance to offer a pep talk or tactical advice to their team via the #ThreeTalk hashtag and the official Twitter account @Only1Argyle.
#threetalk gotta be for the fans just show them some fight out there and they'll be behind you, be brave and win ugly if need be! Go get it!— Jamie Todd (@MrTodd91) January 29, 2015
That advice will be compiled and shown to the team before kick-off this Saturday.
The tie-up will also allow Plymouth fans to ‘stay connected’ during the journey to the game, with all official coaches equipped with Wi-Fi. Plymouth's management and players have also been handed devices running on Three's network to document the game via social media.
Three is offering other benefits in the week running up to the match, including the chance for supporters to win a training session with the team by submitting a selfie in which they're wearing a team top.
Three’s director of brand and communications, Lianne Norry, said: "No matter which team you support, the one thing all football fans have in common is their love for their club.
"That's why we're delighted to sponsor Plymouth Argyle's away game so we can connect the club with its fans and keep them close together even though they are traveling 774 miles for this game."