The agency was appointed without a pitch and is tasked with promoting the football club's hospitality facilities to companies that are not part of its membership programme.
OgilvyOne's first work will be a DM campaign explaining how corporate hospitality is a good way to cement relationships and network with existing and prospective clients.
The work will invite companies to sign up for the club's corporate sponsorship programme. It will include a data capture element, which will then be used for a customer relationship drive.
Mike Dodds, the managing director of OgilvyOne, said: "Spurs are at an exciting point in their history. Our team is relishing the chance to capitalise on the opportunities for corporate entertainment with one of the world's most famous football clubs."
Spurs' White Hart Lane ground plays host to 3,000 corporate hospitality guests at each match. It has 120 executive boxes, each of which can hold eight to 20 seats.