The MCBD creative team Dave Hobbs and Richard Stoney won November's Award, held in association with Campaign, for a new Travelocity execution entitled "helium".
The ad features Alan Whicker inhaling helium in a hot-air balloon over Kenya.
This month's Aerials judge, Will Awdry, the creative director of DDB London, said: "I had admired the Travelocity campaign along with everyone else, but the 'helium' radio ad is a work of genius."
This is the fourth Aerial MCBD's Travelocity work has won. Last month, it scooped the gold award at the annual Aerials final.
The joint runners-up were two ads for Mothercare, both of which were written by Alan Young, Julian Vizard and Tim Collins from St Luke's.