The "Welcome to my world" campaign, created by Rainey Kelly Campbell Roalfe Y&R, will reveal London through the eyes of Londoners with tips on where to go, neighbourhoods to explore, events, and ways to make the dollar go further.
The campaign will run across radio, print and online in key cities including New York, Chicago, Miami, Los Angeles and San Francisco. In Canada activity will be focused on Vancouver and Toronto.
Visit London said that it is also offering special flight promotions from British Airways and discounted hotel rates from Radisson Edwardian to make London even more affordable as a holiday destination.
The North American campaign follows Visit London's European activity, which kicked off last week, and is part of the tourism body's four month international marketing campaign aimed at stimulating visits to the capital during the economic downturn.
Visit London is promoting 2009 as an especially good year to visit London with events including Hampton Court Palace and the Tower of London celebrating the accession of Henry VIII to the throne, Kew Gardens having its 250th anniversary and the Natural History Museum is commemorating Charles Darwin's birth.
Sally Chatterjee, Visit London's interim CEO, said: "Now is the best time for visitors from North America to travel to London, the exchange rate means that the dollar will go further and visitors can still take advantage of all London's free attractions."