The campaign, which focuses on W&DB's draft ale Marstons Pedigree, launches on 9 December and will run on 96-sheet and 48-sheet posters and bus sides.
It will also be appearing in national and regional press and at Derby County football club's Pride Park ground.
Each of the nine executions features a pint of Marstons carrying a label that reads "still brewed in wood", highlighting the fact that Pedigree is still made using the same Burton Union system that has always been used. The image of the pint is juxtaposed with endlines such as "uncompromising" or "corners uncut".
The "uncompromising" theme has been integrated into all promotional and point- of-sale materials in pubs as well as through the website www.uncompromising.co.uk.
Peter Jackson, the director of marketing at W&DB, said: "We have an unswerving commitment to brewing beer of the highest quality, which is what the trade and drinkers want. Walsh Trott has created a big idea for us that has captured this uncompromising attitude perfectly."
The campaign was written by Dave Trott and art directed by Gordon Smith.
Media was planned and bought by Manning Gottlieb OMD.