The campaign aims to demonstrate the possibilities for content creators and brands that use YouTube to reach audiences.
Spencer Berwin, the managing director of sales at JCDecaux, said: "Old Street EC1 delivers the influential audiences that brands need – from the tech communities, to the city-workers and fashionistas.
"Digital brings a new level of engagement to our medium and we are delighted to see YouTube deploy this exciting new channel to its full creative potential, putting their vloggers centre stage in the heart of Tech City."
A wider campaign will run across Google-owned properties as well as TV, print and out-of-home screens.
Jamie Finn, a business director at Talon, said: "[Old Street EC1] ties in perfectly with our campaign objectives for YouTube, reaches a valuable audience, and a site of this scale allows us to make a big impact in a unique area of London."
Old Street EC1 forms part of JCDecaux’s portfolio of digital screens, adding to its locations in Waterloo, Liverpool Street and Euston stations.
For insight, news and comment on Old Street EC1 visit www.brandrepublic.com/ec1